It is a surfactant functioning both as cleansing and solubilizing agent. Despite their wide range of applications, limited analytical techniques have been reported in. Besides, the difference in the sound speed between the free water and water interacting with the poloxamer is not relevant. Thermogelling properties of purified poloxamer 407. Cupric chloride anhydrous 222011 was purchased from aldrich st. Lutrol f 68 meets the requirements of the current uspnf family monograph, poloxamer. Poloxamer 105 benzoate is an ester of poloxamer 105 and benzoic acid and poloxamer 182 dibenzoate is the diester of poloxamer 182 and benzoic acid gottschalck and mcewen 2004. Poloxamers are another type of thermosensitive hydrogels with an abatype triblock structure fig. Mechanism investigation for poloxamer 188 raw material variation. Because the lengths of the polymer blocks can be customized, many different poloxamers exist that have slightly different properties. They also improve the water solubility of the coating. Kolliphor p 338 is used primarily as thickening agent and gel former, but also as coemulsifier and consistency enhancer in creams and liquid emulsions, i. Variable rh raman data p338 p407 surface measurement systems.
Differential effects of commercialgrade and purified. Safety assessment of poloxamers 101, 105, 108, 122, 123, 124, 181. Poloxamer chemical composition, chemistry information, uses and benefits subject find chemical composition, chemistry information, uses and benefits details of poloxamer active pharmaceutical ingredient in pdf document at. Emm 070801e00 january 2008 page 4 of 10 pluracare lf grades poloxamer applications it is suggested that these pluracare copolymers be considered for their general functionality as surfactants, emulsifiers, solubilizers and stabilizers in almost all. Through science and innovation we provide our customers with products to meet the current and future needs of business and society.
Basf to develop a high purity poloxamer for mast therapeutics. Its physicochemical and application relevant characteristics are attributed to. Find pharmaceutical excipients from basf containing poloxamer 338 to address your drug development formulation challenges. A nonionic surfactant that has general functionality of surfactant, emulsifier, solubilizer and stabilizer. Linear aminoterminated poly ethylene glycol methyl ethers mpegnh 2 were purchased from jenkem technology co. A read is counted each time someone views a publication summary such as the title, abstract, and list of authors, clicks on a figure, or views or downloads the fulltext. You can find detailed information on our product range by looking up your industry or using our product finder. Poloxamer 407mediated alterations in the activities of. Safety assessment of poloxamers 101, 105, 108, 122, 123, 124. View poloxamer 338 pharma excipient products by basf. The process involves premelting the poloxamer prior to mixing with cold water. Polyurethane basic products pu solutions elastogran. Accelon is a breakthrough omega3 technology that significantly accelerates omega3 absorption, so you get more omega3 to where its needed.
Pluracare f 127 prill dewolf chemical an azelis company. Effect of poloxamer 407 as a carrier vehicle on rotator cuff. Poloxamers are nonionic triblock copolymers composed of a central hydrophobic chain of. Addition of free poloxamer 407 to a new gene vector p407. Technical information pluracare lf grades poloxamer.
The common available grades are poloxamer 68, 88, 98, 108, 124, 188, 237, 338, and 407. Generally, poloxamer micelles in aqueous solution are spherical with a coreshell structure figure1 54,55. All poloxamer are chemically similar in composition, differing only in the relative amounts of propylene and ethylene oxides. Pharmaceutics free fulltext poloxamer hydrogels for. Poloxamer 188 solution 10%, sterilefiltered, bioreagent. Variable rh raman data p338 p407 surface measurement. Evaluation of thermosensitive poloxamer 407 gel systems for. Generally, poloxamer micelles in aqueous solution are spherical with a coreshell structure. Assessment of transdermal penetration enhancement by topical. It possesses solubilizing, bodying and gelling properties. Makon l61 poloxamer 181 liquid 3 2,000 24 32 162 makon l62 poloxamer 182 liquid 7 2,500 32 41 268 makon l64 poloxamer 184 liquid 15 2,900 58 18 312 makon l101 poloxamer 331 liquid 1 3,800 15 36 392 makon p6575 na paste 17 3,800 82 27 2222 makon p104 poloxamer 334 paste 5,900 82 32 4482 makon p105 poloxamer 335 paste 15 6,500 631 36 6262.
Kolliphor p 188 is an poloxamer that enables and enhances a wide range of. Electrospraying poloxamerbiopolymer blends using a. The approximate lengths of the two peg blocks is 101 repeat units while the approximate length of the propylene. Basf pharmaceuticalgrade ingredients for the dermatology industry. Apr 17, 2020 they are used in pharmaceutical formulations as surfactants, emulsifying agents, solubilizing agent, dispersing agents, and as in vivo absorbance enhancers. Kolliphor rh 40 basf hydrogenated castor oil, uspnf, ph. Kolliphor p 338 can be used as solubilizer, emulsifier and plasticizer. Quantitation of pluronics by high performance liquid. Pdf poloxamer 407induced atherogenesis in the c57bl6 mouse. Poloxamers, which are used as a drug delivery system and an adhesion barrier, is a polymer produced by basf. Basf corporation was supported on a polystyrene divinyl benzene solid matrix xad4.
Poloxamerbased in situ hydrogels for controlled delivery of. Fluorescence probe studies using pyrene show that the micelle core is hydrophobic. Pluracare f 127 prill is a copolymer of ethylene oxide and propylene oxide with an average molecular weight of 12,600. Quantitation of pluronics by high performance liquid chromatography and corona charged aerosol detection marc plante, bruce bailey, ian n.
The effectiveness of poloxamer 407based new antiadhesive. The material used in this study is a physical mixture that is mainly composed of poloxamer 407 23 wt. The right solution for your formulation challenge basf. Poloxamer with its synonym as polyethylenepropylene glycol copolymer and trade names as supronic, pluronic or tetronic have been introduced in 1950 as a nonionic triblock copolymer. Since then we have continuously expanded our solution offer. The formulation selected from the rheological analysis poloxamer 21% ww, nacl 0. Poloxamer 188 solution 10%, sterilefiltered, bioreagent, suitable for insect cell culture synonym. Basf poloxamers offer better solubilizing properties compared to hpmc, pvp.
Under the agreement between basf and mast, basf will develop a higher purity poloxamer 188 and provide mast with clinical quantities of the new material to be used for specific therapeutic. Poloxamer 407 is a hydrophilic non ionic surfactant of the more general class of copolymers known as poloxamers. Then, the impact of poloxamer 407 concentration on gel formation was evaluated. About fagron fagrons strategy is focused on the optimization and innovation of pharmaceutical compounding. Poloxamer 407 pluronic f127, peo 9 9ppo 67 peo 9 9 is widely employed for drug delivery because it is reported to be nontoxic and can form gels at 25 c at a concentration of 20 wt% dumortier et al. Poloxamer 407 has approximate block lengths of a 101 and b 56. Solution s is not more intensely coloured than reference solution by 7 2.
Emulsifier kolliphor tpgs basf dalpha tocopheryl polyethylene glycol succinate, uspnf emulsifier emulgin sg basf sodium stearoyl glutamate emulsifier kolliphor sls basf sodium lauryl sulfate, uspnf, ph. Pdf the present study describes the preparation and evaluation of a poloxamer 407 p407based thermoreversible gel using carbopol 934p c934p as a. Kolliphor hs 15 is an exceptional solubilizer with attributes suited for parenteral and oral formulation of poorly soluble molecules. Us20274421a1 highly pure poloxamers and purification. Pharmaceuticalgrade ingredients for the dermatology industry. Poloxamer 407 pluronic f127 p407 and poloxamer 188 pluronic f68 p188 were purchased from basf china company co. The dvs system provides a wellestablished method for the determination of water sorption and. Physical and chemical properties as described by leaf 1967, many poloxamers dissolve in water and form gels when a concentrated aqueous solution is made. Therefore, at a microrheological level, the interaction with water at the watermicelle interface is definitely lower compared to the unimers interactions before micellization giving rise to a less structured interface. The present invention is directed to a process for producing pharmaceutically acceptable aqueous poloxamer gels in a cost efficient manner. A supercritical fluid extraction process was used to prepare p188p. Water sorption properties measured by dynamic vapor sorption dvs. Us drug master file basf maintains a drug master file for poloxamers at the fda and is familiar with supplying information to the fda to assist customers in obtaining fda authorizations. Ethylene oxide is then added to form the block copolymer.
Acworth thermo fisher scientific, chelmsford, ma, usa conclusions a basic method was developed for quantitation of poloxamers using the acclaim surfactant plus column and the corona ultra rs detector. Effect of poloxamer 407 as a carrier vehicle on rotator. Kolliphor hs 15 an enabler for parenteral and oral. In these systems, the poloxamer acts as a gelling agent, and chitosan as a carrier and bactericidal agent. Poly ethylene glycol block poly propylene glycol block poly ethylene glycol you have selected the maximum number of product attributes 3 to compare. Poloxamers, available also under the trademark pluronics basf, are a. Poloxamer block copolymers are non ionic surfactants available under the.
A poloxamer composition free of long circulating material and methods for. Today we solve unmet formulation needs and offer intelligent solutions for today and tomorrows challenges in. Nov 17, 2014 manufacturing method poloxamer polymers are prepared by reacting propylene oxide with propylene glycol to form polyoxypropylene glycol. Hydrogen peroxide h325100 was purchased from fisher scientific. The impact of poloxamer 407 concentration on gel formation was evaluated and it was confirmed that increasing poloxamer 407 concentration impacted on t solgel, maximum recorded storage modulus, and viscosity with lower amounts of the purified poloxamer 407 needed to reach comparable levels to the unpurified, compendial poloxamer 407. Poloxamer 188, european pharmacopoeia ep reference standard. Poloxamer 407 is a hydrophilic nonionic surfactant of the more general class of copolymers known as poloxamers. The high performance and safety of basf products is backed by comprehensive documentation so you know you can rely on us our flexible kolliphor solutions can be used for hotmelt and spraydrying processes basf poloxamers offer better solubilizing properties compared to hpmc, pvp and cyclodextrins. Among the poloxamers, poloxamer 407 with registered trademarks of pluronic f127 by basf laboratories and synperonic. Mount olive, nj, usa, six were purchased with a cannula having already been placed in the external jugular vein and were used to collect postheparin plasma for hl activity determinations, and four rats were used as controls and blood col. Poloxamer 407 is a triblock copolymer consisting of a central hydrophobic block of polypropylene glycol flanked by two hydrophilic blocks of polyethylene glycol peg. Electrospraying poloxamerbiopolymer blends using a needleless electrospinning machine robin bottjer, timo grothe, daria wehlage, and andrea ehrmann journal of textiles and fibrous materials 2018 10. A polymeric multitalent suitable for a large variety of applications, i. Billerica, ma, which was then added to poloxamerfree cell.
Samples, free of visible air bubbles, were prepared before setting the final. The methods of determination are described in this monograph or in the general methods to be found in the european pharmacopoeia. Poloxamer 184 poloxamer 184 is a polyoxyethylene, polyoxypropylene block polymer. To assess the direct and measurable effect of these two carrier vehicles on rotator cuff tendontobone healing, we applied a collagen sponge or poloxamer 407 to the interface of the detached supraspinatus tendon and footprint in the bone rather than applying these carrier vehicles over the rotator cuff tendontobone repair site.
A total of seven representative p188 lots lot ag, basf. Pluracare l 64 is a copolymer of ethylene oxide and propylene oxide with an average molecular weight of 2,900. Pluronic block copolymer nf grades poloxamer nf grades. Poloxamer hydrogels use in drug release appeared at the beginning of the 1970s. Jigar lalani, ambikanandan misra, in challenges in delivery of therapeutic genomics and proteomics, 2011. Despite their wide range of applications, limited analytical techniques have been reported in literature for characterizing poloxamers and few are.
They are also used in topical dosage forms and rectal suppositories. Poloxamer micellization is thus said to be entropically driven 53. Poloxamer chemical composition, chemistry information, uses. Poloxamer 407induced atherogenesis in the c57bl6 mouse article pdf available in atherosclerosis 61. Thermogelling properties of purified poloxamer 407 sciencedirect. Poloxamers are also known by the trade names synperonics, pluronic, and kolliphor. Safety assessment of poloxamers 101, 105, 108, 122, 123. Pdf poloxamers, poloxamines and polymeric micelles. Poloxamers are nonionic triblock copolymers composed of a central hydrophobic chain of polyoxypropylene polypropylene oxide flanked by two hydrophilic chains of polyoxyethylene polyethylene oxide. Addition of free poloxamer 407 to a new gene vector p407peik12 solution forms a sustainedrelease in situ hypergel that enhances cell transfection and extends gene expression hongmei shu, 1 yaguang zhang, 1 min zhang, 1 junwen wu, 1 mingxiao cui, 1 kehai liu, 1 and jun wang 2. Chemicals are produced in a broad range of rigid twocomponent. Pdf research for new therapies to treat diseases like cancer, it is one. Disclosed are a method for purifying poloxamers, comprising dissolving poloxamers in. By using our services, you agree to our use of cookies.